Research Papers

A curated document list highlighting the utility and performance of LiverMultiScan
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Predicting outcomes
Making patients better
Understanding complexity
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EASL Congress 2024 Alert

Product

Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH

The New England Journal of Medicine
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Cardiovascular imaging in the integrated assessment of metabolic health

Frontiers in Cardiovascular Medicine,
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Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Elastography to evaluate the early effects of bariatric surgery on non-alcoholic liver disease

International Journal of Biomedical Imaging
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Clonal hematopoiesis and risk of chronic liver disease

Nature,
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A Composite Score Using Quantitative Magnetic Resonance Cholangiopancreatography Predicts Clinical Outcomes in Primary Sclerosing Cholangitis

JHep Reports,
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A low energy total diet replacement program demonstrates a favorable safety profile and improves liver disease severity in nonalcoholic steatohepatitis

Obesity
Product

Association of chronic liver disease with cardiovascular outcomes in 33,616 individuals in a prospective UK Biobank study

Journal of Hepatology
Product

Estimation of field inhomogeneity map following magnitude-based ambiguity-resolved water-fat separation

Magnetic Resonance Imaging
Product

Non-invasive diagnosis and monitoring of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

The Lancet: Gastroenterology & Hepatology
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Quantitative MRCP-derived PSC (qMRCP-PSC) score: an artificial-intelligence derived model for medium-term outcome prediction in primary sclerosing cholangitis

Digestive and Liver Disease
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Quantitative magnetic resonance cholangiography derived biliary metrics are associated with disease severity and clinical outcomes in patients with Primary Sclerosing Cholangitis

JHEP Reports
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Quantitative MR in paediatric patients with Wilson disease: a case series review.

Children
Product

Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection

Open Heart
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Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study

Journal of the Royal Society of Medicine
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Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants

Nature Communications
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Quantitative imaging tests for non-alcoholic fatty liver disease: which, when and why

Translational Gastroenterology and Hepatology
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Corrected T1 Mapping in Children and Young Adults With Autoimmune Liver Disease: Correlation With Histology

American Journal of Roentgenology
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Greater ectopic fat deposition and liver fibroinflammation and lower skeletal muscle mass in people with type 2 diabetes.

Obesity
Product

Quantitative magnetic resonance imaging to aid clinical decision making in autoimmune hepatitis

EClinicalMedicine
Product

Pancreas MRI Segmentation Into Head, Body, and Tail Enables Regional Quantitative Analysis of Heterogeneous Disease

Journal of Magnetic Resonance Imaging
Product

Technology-Enabled, Evidence-Driven, and Patient-Centered: The Way Forward for Regulating Software as a Medical Device.

JMIR Medical Informatics
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The Additive Value of Cardiovascular Magnetic Resonance in Convalescent COVID-19 Patients

Frontiers in Cardiovascular Medicine,
Product

Precision medicine for liver tumours with quantitative MRI and whole genome sequencing (Precision1 trial): study protocol for observational cohort study.

BMJ Open
Product

Quantitative MR in Paediatric Patients with Wilson Disease: A Case Series Review

Children
Product

Rapid quantification of myocardial lipid content in humans using single breath‐hold 1H MRS at 3 Tesla

Magnetic Resonance in Medicine
Product

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

2014
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Evidence of a Direct Effect of Myocardial Steatosis on LV Hypertrophy and Diastolic Dysfunction in Adult and Adolescent Obesity

JACC: Cardiovascular Imaging
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Sex-specific differences in hepatic fat oxidation and synthesis may explain the higher propensity for NAFLD in men

Journal of Clinical Endocrinology and Metabolism
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Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
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Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease

Journal of Hepatology
Product

Investigating a Liver Fat: Arterial Stiffening Pathway in Adult and Childhood Obesity

Arteriosclerosis Thrombosis and Vascular Biology
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Decision analytic model of the diagnostic pathways for patients with suspected non-alcoholic fatty liver disease using non-invasive transient elastography and multiparametric magnetic resonance imaging

BMJ Open
Product

Ectopic and visceral fat deposition in lean and obese patients with Type 2 Diabetes

Journal of the American College of Cardiology
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Patient reported assessment of different diagnostic imaging tests for liver disease visual representation and ownership of results improves understanding.

Hepatology
Product

Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease

Alimentary Pharmacology & Therapeutics
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Characterisation of liver fat in the UK Biobank cohort

PLoS One
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Multi-parametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity

Liver International
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A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look‐Locker inversion recovery T1 (shMOLLI‐T1) in the liver

Journal of magnetic resonance imaging : JMRI
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Interobserver Variability in Histologic Evaluation of Liver Fibrosis Using Categorical and Quantitative Scores

American Journal of Clinical Pathology
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Non-invasive assessment of liver disease in rats using multiparametric magnetic resonance imaging: a feasibility study

Biology Open
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Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study

Scientific Reports
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Study protocol: HepaT1ca – an observational clinical cohort study to quantify liver health in surgical candidates for liver malignancies

BMC Cancer
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Utility and variability of three non-invasive liver fibrosis imaging modalities to evaluate efficacy of GR-MD-02 in subjects with NASH and bridging fibrosis during a phase-2 randomized clinical trial

PLOS ONE
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Mapping tissue water T1 in the liver using the MOLLI T1 method in the presence of fat, iron and B0 inhomogeneity

NMR in Biomedicine
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Validation of a standardized MRI method for liver fat and T2* quantification

PLOS ONE
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The cT1 multi-parametric MRI value is more sensitive and reliable than transient elastography for the non-invasive monitoring of intra-hepatic inflammation/fibrosis response to DAA therapy in CHC patients

Hepatology
Product

Liver cT1 predicts clinical outcomes in patients with chronic liver disease, equivalent to biopsy

Hepatology
Product

Multi-parametric MRI as a composite biomarker for NASH and NASH with fibrosis

Hepatology
Product

Multi-parametric MRI imaging in a heterogeneous liver disease: cross-sectional evaluation of a cohort of patients with PSC

Hepatology
Product

Cross-sectional, prospective, evaluation of the utility of Multi-parametric MRI imaging in predicting clinically meaningful outcomes in autoimmune hepatitis

AASLD ABSTRACTS (Poster)
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Multiparametric magnetic resonance imaging for early detection of diffuse liver disease

Biomarkers in Medicine
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[Poster] The “IDEAL” method for fat quantification and iron-corrected T1 accurately measure the presence and severity of the individual histological features of nonalcoholic steatohepatitis (NASH)

Hepatology
Product

Aldon.knolls@perspectum.com

Journal of Hepatology
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Measurement of liver iron by magnetic resonance imaging in the UK Biobank population

PLOS ONE
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Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases

Abdominal Radiology
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Diagnostic performance of quantitative magnetic resonance imaging biomarkers for predicting portal hypertension in children and young adults with autoimmune liver disease.

Radiology
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NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis

Journal of Hepatology
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Magnitude‐intrinsic water–fat ambiguity can be resolved with multipeak fat modeling and a multipoint search method

Magnetic Resonance in Medicine
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Repeatability and reproducibility of multiparametric magnetic resonance imaging of the liver

PLOS ONE
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Non-invasive assessment of portal hypertension by multi-parametric magnetic resonance imaging of the spleen: A proof of concept study

PLOS ONE
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Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

Journal of Hepatology
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Sodium-glucose cotransporter 2 inhibition does not reduce hepatic steatosis in overweight, insulin-resistant patients without type 2 diabetes

JGH Open
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Differentiating pediatric autoimmune liver diseases by quantitative magnetic resonance cholangiopancreatography

Abdominal Radiology
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Nutrition and Nonalcoholic Fatty Liver Disease: Current Perspectives

Gastroenterology Clinics
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Primary biliary cholangitis (PBC)

Journal of Magnetic Resonance Imaging
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Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis

Journal of Hepatology
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Relationship between magnetic resonance imaging spleen T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis in children and young adults with autoimmune liver disease.

Abdominal Radiology
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Comparison of liver T1 relaxation times without and with iron correction in pediatric autoimmune liver disease

Pediatric Radiology
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New boundaries of liver imaging: from morphology to function

European Journal of Internal Medicine
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Mechanisms, screening modalities and treatment options for individuals with non-alcoholic fatty liver disease and type 2 diabetes

Diabetic medicine
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Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood-based fibrosis markers in patients with chronic liver disease

Liver international
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Multiparametric MR mapping in clinical decision-making for diffuse liver disease

Abdominal Radiology
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Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease

Journal of Magnetic Resonance Imaging
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rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis

Journal of Hepatology
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A composite biomarker using multiparametric magnetic resonance imaging and blood analytes accurately identifies patients with non-alcoholic steatohepatitis and significant fibrosis

Scientific Reports
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Multiparametric MRI as a non-invasive monitoring tool for children with autoimmune hepatitis

Journal of Pediatric Gastroenterology and Nutrition
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The Effect of Multiparametric Magnetic Resonance Imaging in Standard of Care for Non-alcoholic Fatty Liver Disease: Protocol for a Randomised Control Trial

JMIR Research Protocols
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Serum Matrix Metalloproteinase 7 Is a Diagnostic Biomarker of Biliary Injury and Fibrosis in Pediatric Autoimmune Liver Disease

Hepatology Communications
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Quantitative magnetic resonance imaging predicts individual future liver performance after liver resection for cancer

PLOS ONE
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Liver cT1 decreases following direct-acting antiviral therapy in patients with chronic hepatitis C virus

Abdominal Radiology
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Correlations between MRI biomarkers PDFF and cT1 with histopathological features of non-alcoholic steatohepatitis

Frontiers in Endocrinology
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Quantitative multiparametric MRI can aid NASH diagnosis in a Japanese cohort

World Journal of Gastroenterology
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Multiparametric MRI imaging, autoimmune hepatitis, and prediction of disease activity

Hepatology Communications
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Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: report of two patients

BJR | case reports
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Hepatic steatosis rather than underlying obesity increases risk of infection and hospitalization for COVID-19

Frontiers in Medicine Gastroenterology
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Prospective evaluation of the prevalence of nonalcoholic fatty liver disease and steatohepatitis in a large middle-aged United States cohort

Journal of Hepatology
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Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study

BMJ Open
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Comparison between magnetic resonance and ultrasound-derived indicators of hepatic steatosis in a pooled NAFLD cohort

PLOS ONE
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Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial

Molecular Nutrition & Food Research
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Incidence of complications from percutaneous biopsy in chronic liver disease: a systematic review and meta-analysis

Digestive Diseases and Sciences
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Evaluation of quantitative MRCP (MRCP+) for risk stratification of primary sclerosing cholangitis: comparison with morphological MRCP, MR elastography, and biochemical risk scores

European Radiology
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Quantitative multiparametric MRI as a non-invasive stratification tool in children and adolescents with autoimmune liver disease

Scientific Reports
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A 3D Quantitative MRC Modeling Images Detected Case of Intrahepatic Biliary Stricture Diseases

Case Reports in Gastroenterology
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Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease

The American Journal of Gastroenterology
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Longitudinal Changes in Quantitative Magnetic Resonance Imaging Metrics in Children and Young Adults with Autoimmune Liver Disease

Journal of Abdominal Radiology
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Associations Between Quantitative MRI Metrics and Clinical Risk Scores in Children and Young Adults With Autoimmune Liver Disease

American Journal of Roentgenology
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Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: diagnostic and mechanistic relevance

JHEP Reports
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Associations between MRI T1 mapping, liver stiffness, quantitative MRCP, and laboratory biomarkers in children and young adults with autoimmune liver disease.

Mahalingam, N., Trout, A. T., Gandhi, D. B., Sahay, R. D., Singh, R., Miethke, A. G., Dillman, J. R.
Product

Patient understanding and experience of non-invasive imaging diagnostic techniques and the liver patient pathway

Journal of Patient-Reported Outcomes
LiverMultiScan Home
Full Publication List
Full publication list
Publication:
Estimation of field inhomogeneity map following magnitude-based ambiguity-resolved water-fat separation
Publication:
Non-invasive diagnosis and monitoring of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Publication:
Quantitative MR in paediatric patients with Wilson disease: a case series review.
Publication:
Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants
Publication:
Quantitative imaging tests for non-alcoholic fatty liver disease: which, when and why
Publication:
Corrected T1 Mapping in Children and Young Adults With Autoimmune Liver Disease: Correlation With Histology
Publication:
Greater ectopic fat deposition and liver fibroinflammation and lower skeletal muscle mass in people with type 2 diabetes.
Publication:
Quantitative magnetic resonance imaging to aid clinical decision making in autoimmune hepatitis
Publication:
Technology-Enabled, Evidence-Driven, and Patient-Centered: The Way Forward for Regulating Software as a Medical Device.
Publication:
Precision medicine for liver tumours with quantitative MRI and whole genome sequencing (Precision1 trial): study protocol for observational cohort study.
Publication:
Quantitative MR in Paediatric Patients with Wilson Disease: A Case Series Review
Publication:
Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease
Publication:
Multiparametric magnetic resonance imaging predicts clinical outcomes in patients with chronic liver disease
Publication:
Decision analytic model of the diagnostic pathways for patients with suspected non-alcoholic fatty liver disease using non-invasive transient elastography and multiparametric magnetic resonance imaging
Publication:
Ectopic and visceral fat deposition in lean and obese patients with Type 2 Diabetes
Publication:
Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease
Publication:
Characterisation of liver fat in the UK Biobank cohort
Publication:
Multi-parametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease severity
Publication:
A model for hepatic fibrosis: the competing effects of cell loss and iron on shortened modified Look‐Locker inversion recovery T1 (shMOLLI‐T1) in the liver
Publication:
Multiparametric magnetic resonance imaging for quantitation of liver disease: a two-centre cross-sectional observational study
Publication:
Validation of a standardized MRI method for liver fat and T2* quantification
Publication:
The cT1 multi-parametric MRI value is more sensitive and reliable than transient elastography for the non-invasive monitoring of intra-hepatic inflammation/fibrosis response to DAA therapy in CHC patients
Publication:
Liver cT1 predicts clinical outcomes in patients with chronic liver disease, equivalent to biopsy
Publication:
Multi-parametric MRI as a composite biomarker for NASH and NASH with fibrosis
Publication:
Multi-parametric MRI imaging in a heterogeneous liver disease: cross-sectional evaluation of a cohort of patients with PSC
Publication:
Cross-sectional, prospective, evaluation of the utility of Multi-parametric MRI imaging in predicting clinically meaningful outcomes in autoimmune hepatitis
Publication:
Multiparametric magnetic resonance imaging for early detection of diffuse liver disease
Publication:
[Poster] The “IDEAL” method for fat quantification and iron-corrected T1 accurately measure the presence and severity of the individual histological features of nonalcoholic steatohepatitis (NASH)
Publication:
Reference range of liver corrected T1 values in a population at low risk for fatty liver disease—a UK Biobank sub-study, with an appendix of interesting cases
Publication:
Diagnostic performance of quantitative magnetic resonance imaging biomarkers for predicting portal hypertension in children and young adults with autoimmune liver disease.
Publication:
NGM282 Improves Liver Fibrosis and Histology in 12 Weeks in Patients With Nonalcoholic Steatohepatitis
Publication:
Magnitude‐intrinsic water–fat ambiguity can be resolved with multipeak fat modeling and a multipoint search method
Publication:
Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration
Publication:
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis
Publication:
Relationship between magnetic resonance imaging spleen T1 relaxation and other radiologic and clinical biomarkers of liver fibrosis in children and young adults with autoimmune liver disease.
Publication:
Comparison of liver T1 relaxation times without and with iron correction in pediatric autoimmune liver disease
Publication:
Prognostic value of multiparametric magnetic resonance imaging, transient elastography and blood-based fibrosis markers in patients with chronic liver disease
Publication:
Multiparametric MR mapping in clinical decision-making for diffuse liver disease
Publication:
Multiparametric MRI in Patients With Nonalcoholic Fatty Liver Disease
Publication:
rs641738C>T near MBOAT7 is associated with liver fat, ALT, and fibrosis in NAFLD: a meta-analysis
Publication:
A composite biomarker using multiparametric magnetic resonance imaging and blood analytes accurately identifies patients with non-alcoholic steatohepatitis and significant fibrosis
Publication:
Multiparametric MRI as a non-invasive monitoring tool for children with autoimmune hepatitis
Publication:
Liver cT1 decreases following direct-acting antiviral therapy in patients with chronic hepatitis C virus
Publication:
Correlations between MRI biomarkers PDFF and cT1 with histopathological features of non-alcoholic steatohepatitis
Publication:
Quantitative multiparametric MRI can aid NASH diagnosis in a Japanese cohort
Publication:
Multiparametric MRI imaging, autoimmune hepatitis, and prediction of disease activity
Publication:
Quantitative multiparametric MRI allows safe surgical planning in patients undergoing liver resection for colorectal liver metastases: report of two patients
Publication:
Hepatic steatosis rather than underlying obesity increases risk of infection and hospitalization for COVID-19
Publication:
Prospective evaluation of the prevalence of nonalcoholic fatty liver disease and steatohepatitis in a large middle-aged United States cohort
Publication:
Comparison between magnetic resonance and ultrasound-derived indicators of hepatic steatosis in a pooled NAFLD cohort
Publication:
Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial
Publication:
Quantitative multiparametric MRI as a non-invasive stratification tool in children and adolescents with autoimmune liver disease
Publication:
Safety, Tolerability, and Biologic Activity of AXA1125 and AXA1957 in Subjects With Nonalcoholic Fatty Liver Disease
Publication:
Longitudinal Changes in Quantitative Magnetic Resonance Imaging Metrics in Children and Young Adults with Autoimmune Liver Disease
Publication:
Associations Between Quantitative MRI Metrics and Clinical Risk Scores in Children and Young Adults With Autoimmune Liver Disease
Publication:
Associations between MRI T1 mapping, liver stiffness, quantitative MRCP, and laboratory biomarkers in children and young adults with autoimmune liver disease.
Publication:
Patient understanding and experience of non-invasive imaging diagnostic techniques and the liver patient pathway
Publication:
Clinical utility of MRI biomarkers for identifying NASH patients at high risk of progression: A multi-center pooled data and meta-analysis